A humanized Aβ mouse model reveals E4-dependent cognitive impairments, microglial activation, and cerebrovascular dysfunction
Skylyn J. Ferguson, Claudia Pelayo, Siena Stueland, Kennedy Krajack, Kiara Gardley, Robert Herbert, Caitlin Tafoya, Alexandra Famiano, Abigail E. Cullen, Naly Setthavongsack, Randall L. Woltjer, Ashley E. Walker
This study uses a humanized Aβ mouse model to show that E4 genotype leads to cognitive impairments, microglial activation, and cerebrovascular dysfunction, with greater effects in females.
bioRxiv · Jul 28, 2026 · PreprintPhysiology