Author

Alexandra Famiano

University of OregonORCID 0009-0006-5897-8994Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Abigail E. CulleniD· 2 shared Ashley E. WalkeriD· 2 shared Caitlin Tafoya· 1 shared Carrie E. McCurdyiD· 1 shared Claudia Pelayo· 1 shared Daniel J. TyrrelliD· 1 shared Kennedy Krajack· 1 shared Kiara Gardley· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

Abigail E. CullenORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintJul 28, 2026

A humanized Aβ mouse model reveals E4-dependent cognitive impairments, microglial activation, and cerebrovascular dysfunction

Skylyn J. Ferguson, Claudia Pelayo, Siena Stueland…·Ashley E. Walker

This study uses a humanized Aβ mouse model to show that E4 genotype leads to cognitive impairments, microglial activation, and cerebrovascular dysfunction, with greater effects in females.

DOI 10.64898/2026.07.28.740806

mouseexperimental assay

𝕏 PostBluesky

PhysiologybioRxivPreprintJul 23, 2025

APOE4 genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function

Mackenzie N. Kehmeier, Alexandra Famiano, Abigail E. Cullen…·Ashley E. Walker

This study shows that 17β-estradiol improves cerebrovascular endothelial and mitochondrial function in APOEε3 mice but not in APOEε4 mice.

DOI 10.1101/2025.07.23.666474

mouseexperimental assay

𝕏 PostBluesky