Randall L. Woltjer

This study shows that stroke and Alzheimer's disease independently affect neurovascular function but together increase amyloid deposition in Tg2576 mice.

This study uses a humanized Aβ mouse model to show that E4 genotype leads to cognitive impairments, microglial activation, and cerebrovascular dysfunction, with greater effects in females.

This study shows that aging rhesus macaques exhibit age-dependent perivascular space burden, mirroring human patterns, and validates MRI-detected structures as perivascular spaces.

This study shows that Robo4 deletion increases neuroinflammation and impairs motor coordination in Alzheimer's disease mice, with effects dependent on AD mutations and brain region.

This study identifies proteins and networks associated with behavioral and psychological symptoms of dementia using proteomic data from multiple cohorts.

This study investigates the protective effects of the APOE CC mutation against Aβ, tau, and α-synuclein pathologies in mouse models of neurodegenerative diseases.

This study examines cerebral blood flow and reactivity in elastin haploinsufficient and 3xTg-AD mice, finding impaired cerebrovascular reactivity in combined genotypes.

The paper introduces a novel mouse model of mild subcortical stroke and shows that astrogliosis spreads widely and independently of microglia and age.

This study shows alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma cells, affecting genomic stability and cancer progression.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

The paper introduces sciMAP-ATAC, a method for spatially resolved single-cell chromatin accessibility profiling, and applies it to study cortical lamination, spatial trajectories, and ischemic infarct progression in mouse and human tissues.

The paper examines GPR39 localization in aged human brains and correlates its expression and polymorphism with vascular cognitive impairment.

The paper identifies unique REST binding sites in human hippocampus compared to mouse and other human cell types, suggesting species-specific roles in brain health.