Ashley E. Walker

This study uses a humanized Aβ mouse model to show that E4 genotype leads to cognitive impairments, microglial activation, and cerebrovascular dysfunction, with greater effects in females.

This study investigates how APOE4 genotype and old age interact to affect cerebrovascular function, brain volume, and neuroinflammation in mice, finding that the interaction impacts these outcomes while age alone affects cognitive function and arterial stiffness.

This study shows that Robo4 deletion increases neuroinflammation and impairs motor coordination in Alzheimer's disease mice, with effects dependent on AD mutations and brain region.

This study examines how age and sex affect cerebral and large artery stiffness and their response to pulse pressure in mice, finding that young females have more compliant arteries susceptible to endothelial dysfunction.

This paper characterizes cerebrovascular phenotypes in WSB.APP/PS1 mice, showing age-related CAA, transcriptomic overlap with human AD, myelin deficits, and APOE allele-dependent effects on vascular pathology.

This study examines cerebral blood flow and reactivity in elastin haploinsufficient and 3xTg-AD mice, finding impaired cerebrovascular reactivity in combined genotypes.

This study shows that 17β-estradiol improves cerebrovascular endothelial and mitochondrial function in APOEε3 mice but not in APOEε4 mice.