Regional macrophage specialization shapes intestinal neuroimmune function
Khaled Warasnhe, Juan Sebastian Ortiz Colmenares, Mario D’Ambrosio, Biagio Di Lorenzo, Yuanhang Liu, Sihan Ji, Magdalini Mischopoulou, Natalie R. Wertish, Mohamed H. Eldesouki, Xinyi Chai, Jean Xin Jiang, Madhusudan Grover, Keith A. Sharkey, Arthur Beyder, Gianluca Cipriani
This study shows that intestinal macrophages have region-specific trophic requirements and neuroimmune functions, with CSF1 playing a key role in small-intestinal nitrergic neuron-macrophage interactions.
bioRxiv · Oct 15, 2026 · PreprintNeuroscience