Mario D’Ambrosio

This study shows that intestinal macrophages have region-specific trophic requirements and neuroimmune functions, with CSF1 playing a key role in small-intestinal nitrergic neuron-macrophage interactions.

This study identifies maladaptive Piezo1 mechanotransduction as a driver of smooth muscle aging in the gut, showing it impairs contractility and contributes to gastrointestinal dysfunction.

This study identifies C1qa⁺ muscularis macrophages as regulators of enteric synaptic homeostasis and gastrointestinal motility through complement-dependent mechanisms.