Jean Xin Jiang

Regional macrophage specialization shapes intestinal neuroimmune function

This study shows that intestinal macrophages have region-specific trophic requirements and neuroimmune functions, with CSF1 playing a key role in small-intestinal nitrergic neuron-macrophage interactions.

Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis

This study shows that targeting macrophage connexin 43 hemichannels reduces synovial inflammation and slows osteoarthritis progression in mice and human cells.

Integrated analysis of stemness-associated immune modulatory circuits in squamous cell carcinomas

The paper identifies SOX2 as a master regulator of immune modulatory circuits in tumor-initiating stem cells, enabling immunosuppressive myeloid cell development.

Pi16+ fibroblast-derived Csf1 shapes skin topography

The paper investigates the role of Pi16+ fibroblasts in regulating macrophage homeostasis and skin architecture by analyzing the effects of Csf1 deletion in these cells.

Basophils drive the resolution and promote wound healing in adult and aged mice

This study shows basophils promote inflammation resolution and wound healing in both adult and aged mice by driving tissue remodeling and immunoregulatory functions.

Dermatopontin-expressing fibroblasts mediate an essential skin macrophage niche

This study identifies Dpt+ fibroblasts as essential for maintaining a Csf1-dependent macrophage niche in skin, with implications for wound healing and scleroderma.