The Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
Mateusz C. Ambrozkiewicz, Ekaterina V. Borisova, Manuela Schwark, Silvia Ripamonti, Theres Schaub, Смородченко Алина Тихоновна, A Ioana Weber, Hong Jun Rhee, Bekir Altas, Rüstem Yilmaz, Susanne G. Mueller, Lars Piepkorn, Stephen T. Horan, Rachel Straussberg, Sami Zaqout, , Hiroshi Kawabe
This study shows that Ube3b regulates dendritic branching and synaptic function by ubiquitinating Ppp3cc, contributing to intellectual disability-like phenotypes in a KOS mouse model.
Molecular Psychiatry · Apr 6, 2020Peer-reviewedNeuroscience