Bekir Altas

VirTarget: Virus-Informed Pharmacogenomics Framework Identifies Immunotherapies That Mitigate Epstein-Barr Virus-Driven Dysregulation in Multiple Sclerosis

VirTarget evaluates MS immunotherapies' effects on EBV-driven dysregulation and host genetics, identifying therapies that reverse or reinforce EBV-MS interactions.

Phosphorylation Determines Whether Neuroligin-3 is at Excitatory or Inhibitory Synapses in Different Regions of the Brain

Cas9 fusions for precision in vivo editing

The paper develops a high-throughput workflow to assess Cas9 editing precision and identifies a novel Cas9 fusion that improves knockin performance in vivo.

Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic manner

This study shows that Ambra1 heterozygosity causes sex-specific reductions in excitatory synaptic activity, leading to E/I imbalance and autism-like behaviors in female mice.

The Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.

This study shows that Ube3b regulates dendritic branching and synaptic function by ubiquitinating Ppp3cc, contributing to intellectual disability-like phenotypes in a KOS mouse model.

Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2

The paper identifies Kir4.1 and Connexin43 as Nedd4-2 substrates, showing their regulation impacts astrocytic function and neuronal network activity.

Correlating Synaptic Ultrastructure and Function at the Nanoscale

The paper investigates ultrastructural differences between Schaffer collateral and mossy fiber synapses to determine their contribution to functional synaptic heterogeneity.