Mateusz C. Ambrozkiewicz

The paper identifies that nucleolar restructuring and Pol1 activity patterns are linked to neuronal subtype identity through dual rRNA-mRNA transcriptomes in developing neocortex.

This study identifies DTX4 as a regulator of neural progenitor transitions during cortical development, showing its role in maintaining radial glia identity and preventing intermediate progenitor generation.

The paper shows UBE3C regulates cortical neurogenesis and glial fate through m6A methylation, with mutations disrupting this process and offering therapeutic targets.

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

The paper measures translation dynamics in mouse neocortex neurogenesis, revealing a critical period of translational control that regulates protein expression and neuronal differentiation.

The paper reveals Ebp1's role in neuronal proteostasis by analyzing ribosomal architecture and proteomic changes in the developing mouse neocortex.

This study shows that Ube3b regulates dendritic branching and synaptic function by ubiquitinating Ppp3cc, contributing to intellectual disability-like phenotypes in a KOS mouse model.