Author

Simon M. Jackson

Amgen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Brandon L. Ason· 2 shared Chi-Ming LiiD· 2 shared J EngreitziD· 2 shared Junedh AmruteiD· 2 shared Maya U. ShethiD· 2 shared Paul P. ChengiD· 2 shared Saptarsi M. HaldariD· 2 shared Thomas QuertermousiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenomics

Brandon L. Ason

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Compact Regulatory Logic Governs Fibroblast Cell State Plasticity in Fibrosis

Ada M. Zhu, Yeting Li, Haiwei Zhang, Brindha Rathinasabapathi, Bastien Cimarosti, Rangarajan D. Nadadur, Vee Xu, Yu Huang, Yuqian An, Kirsten Auclair, Alicja Mahr, Maya U. Sheth, Clara Youngna Lee, Chen Wang, Tracy Yamawaki, , Michael Alexanian

The paper identifies a compact regulatory logic governing fibroblast plasticity in fibrosis by analyzing enhancer repression and gene perturbations across multiple tissues.

bioRxiv · Oct 16, 2026 · PreprintGenomics

Single cell variant to enhancer to gene map for coronary artery disease

Junedh Amrute, Paul C. Lee, Ittai E. Eres, Chang Jie Mick Lee, Andrea L. Bredemeyer, Maya U. Sheth, Tracy Yamawaki, Rijan Gurung, Chukwuemeka George Anene-Nzelu, Wei‐Lin Qiu, Soumya Kundu, Daniel Yuhang Li, Markus O Ramste, Daniel Lu, Anthony S. Tan, , Nathan O. Stitziel

This paper links CAD GWAS variants to causal genes in SMCs using single-cell chromatin accessibility and Hi-C data, creating a scV2E2G map for disease mechanism discovery.

medRxiv · Nov 13, 2024 · PreprintGenetic & Genomic Medicine

Molecular mechanisms of coronary artery disease risk at the PDGFD locus

Hyun-Jung Kim, Paul P. Cheng, Stanislao Igor Travisano, Chad S. Weldy, João P. Monteiro, Ramendra Krishna Kundu, Trieu Nguyen, Disha Sharma, Huitong Shi, Yi Lin, Boxiang Liu, Saptarsi M. Haldar, Simon M. Jackson, Thomas Quertermous

This study identifies PDGFD as a CAD risk gene, showing it promotes SMC expansion, migration, and inflammation, contributing to vascular calcification and plaque recruitment.

Nature Communications · Feb 15, 2023Peer-reviewedGenetics