Author

Anthony S. Tan

Lucile Packard Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:ATAC-seq· 2 Assay:CRISPR screen· 2 Research Focus:database / resource· 2 Approach:experimental assay· 2

Frequent Co-Authors

J EngreitziD· 4 shared Maya U. ShethiD· 4 shared Andreas R. GschwindiD· 3 shared Evelyn Jagoda· 3 shared Lars Michael SteinmetziD· 3 shared Anshul Bharat KundajeiD· 2 shared Benjamin R. DoughtyiD· 2 shared Erez Lieberman AideniD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

J EngreitzORCID

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Author profile →

4 papers

Recent·Most cited

Mapping enhancer-gene regulatory interactions from single-cell data

Maya U. Sheth, Wei‐Lin Qiu, X. Rosa Ma, Andreas R. Gschwind, Evelyn Jagoda, Anthony S. Tan, James Galante, Judhajeet Ray, Dulguun Amgalan, Hjörleifur Einarsson, Bram L. Gorissen, Danilo Dubocanin, Christopher S. McGinnis, Jacob Huang, Glen Munson, , Robin Andersson

The paper introduces scE2G models to predict enhancer-gene regulatory interactions from single-cell data and demonstrates their performance across multiple cell types and perturbations.

Nature Genetics · Aug 1, 2026Peer-reviewedGenetics

Single cell variant to enhancer to gene map for coronary artery disease

Junedh Amrute, Paul C. Lee, Ittai E. Eres, Chang Jie Mick Lee, Andrea L. Bredemeyer, Maya U. Sheth, Tracy Yamawaki, Rijan Gurung, Chukwuemeka George Anene-Nzelu, Wei‐Lin Qiu, Soumya Kundu, Daniel Yuhang Li, Markus O Ramste, Daniel Lu, Anthony S. Tan, , Nathan O. Stitziel

This paper links CAD GWAS variants to causal genes in SMCs using single-cell chromatin accessibility and Hi-C data, creating a scV2E2G map for disease mechanism discovery.

medRxiv · Nov 13, 2024 · PreprintGenetic & Genomic Medicine

Cohesin-mediated 3D contacts tune enhancer-promoter regulation

Philine Guckelberger, Benjamin R. Doughty, Glen Munson, Suhas S.P. Rao, Yingxuan Tan, Xiangmeng Shawn Cai, Charles P. Fulco, Joseph Nasser, Kristy S. Mualim, Drew T. Bergman, Judhajeet Ray, Evelyn Jagoda, Chad J. Munger, Andreas R. Gschwind, Maya U. Sheth, , J Engreitz

This study uses CRUDO to show that cohesin and 3D contacts influence enhancer-promoter regulation, with distal enhancers showing stronger cohesin dependence.

bioRxiv · Jul 12, 2024 · PreprintMolecular Biology

An encyclopedia of enhancer-gene regulatory interactions in the human genome

Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, Maya U. Sheth, Kushal K. Dey, Evelyn Jagoda, Ramil Nurtdinov, Xi Wang, Anthony S. Tan, Hank Jones, X. Rosa Ma, David Yao, Joseph Nasser, Žiga Avsec, Benjamin T. James, , J Engreitz

ENCODE-rE2G, a classifier trained on K562 CRISPR perturbations, maps 13,455,443 enhancer-gene interactions across 352 biosamples, matching or exceeding prior models on CRISPR, eQTL, and GWAS benchmarks.

bioRxiv · Nov 9, 2023 · PreprintGenomics✦ In-depth digest