Structural flexibility of the human vault protein revealed by high-resolution cryo-EM and molecular dynamics simulations
Fabio Lapenta, Karen Palacio‐Rodríguez, Sergio Cruz-León, Simone Marrancone, Jana Aupič, N. Marechal, Alexandre Durand, Dihia Moussaoui, Sonia Covaceuszach, Bhavani Gangupam, Claudia D’Ercole, Cristian Parra, Davide Cotugno, Giulia Tomaino, Paolo Tortora, , Gerhard Hummer
This study uses cryo-EM and molecular dynamics simulations to reveal structural flexibility in the human vault protein, identifying conformational states and dynamic assembly mechanisms.
bioRxiv · Aug 26, 2025 · PreprintBiochemistry