Karen Palacio‐Rodríguez

This study determines the structure of DFCP1 and shows it forms a barrier that concentrates PI3P for lysosomal repair.

The paper elucidates the structural mechanism of nuclear membrane sealing by LEM2-ESCRT-III through a combination of biochemical and structural methods.

The paper identifies lipid specificity in membrane organizing protein complexes by mapping lipid-protein interactions and demonstrating phosphatidylethanolamine's role in stabilizing NDC1 and MIC60.

The paper shows FG-NUPs in live cells exhibit liquid-like mobility, while in vitro they transition to solid, with O-GlcNAcylation and importin-β maintaining the dynamic FG network's liquidity.

This study uses cryo-EM and molecular dynamics simulations to reveal structural flexibility in the human vault protein, identifying conformational states and dynamic assembly mechanisms.