Enhancing mitochondrial activity in neurons protects against neurodegeneration in CNS inflammation
Sina Cathérine Rosenkranz, Artem Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E. Witte, Vanessa Roth, Vanessa Vieira, Nanne J. Paauw, Simone Bauer, Celina Schwencke-Westphal, Lukas Can Bal, Benjamin Schattling, Ole Pleß, Jack van Horssen, Marc Freichel, Manuel Alexander Friese
This study shows that enhancing mitochondrial activity in neurons reduces neurodegeneration during CNS inflammation by improving mitochondrial function and calcium buffering.
bioRxiv · Jun 19, 2020 · PreprintNeuroscience