Marc Freichel

The paper develops a cytosine base editing workflow to generate quality-controlled multiplex-knockout hiPSC lines for studying disease mechanisms.

This study shows JPT2/HN1L is essential for NAADP-mediated Ca2+ release in T cells but not in cardiomyocytes, platelets, or mast cells.

This paper introduces ABE9-SpRY, an improved adenine base editor that generates precise point mutations in mouse embryos with high efficiency and reduced off-target effects.

The paper uses single molecule long-read sequencing to analyze transcriptomes in heart failure patients and controls, identifying novel isoforms and convergent isoform changes across different cardiomyopathy types.

The paper identifies adenosine-specific gene programs in murine mast cells through bulk RNA-Seq, revealing novel mediators and pathways involved in adenosine-evoked inflammation.

This study demonstrates that 5-biotinylation of donor DNA enhances single-copy HDR in mice, achieving 19-26% efficiency in generating conditional alleles.

The paper introduces hei-tag, a tag that enhances CRISPR/Cas9 and base editor efficiency across multiple species and applications.

This study shows that enhancing mitochondrial activity in neurons reduces neurodegeneration during CNS inflammation by improving mitochondrial function and calcium buffering.