Manuel Alexander Friese

This study shows HIV-1 enhances cell-to-cell transmission from infected CD4+ T cells to microglia by altering surface signals and increasing phagocytosis.

This study shows that astrocytic uptake of modified Aβ3(pE)-42 disrupts the endolysosomal system, leading to inflammation and synapse loss in Alzheimer's disease.

The paper shows that Nitarsone prevents Aβ-induced CREB inactivation and synaptic loss in AD models by blocking Jacob-mediated signalosome assembly.

This study shows that enhancing mitochondrial activity in neurons reduces neurodegeneration during CNS inflammation by improving mitochondrial function and calcium buffering.