Nanne J. Paauw

This paper develops a human iPSC-based model of the blood-brain barrier by co-culturing endothelial cells with pericytes and activating Wnt/β-catenin signaling, resulting in cells with BBB-like properties and gene expression patterns.

This study shows that enhancing mitochondrial activity in neurons reduces neurodegeneration during CNS inflammation by improving mitochondrial function and calcium buffering.