Author

Jan Broder Engler

University Medical Center Hamburg-EppendorfORCID 0000-0002-3169-2076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Manuel Alexander FrieseiD· 2 shared Angelique HölzemeriD· 1 shared Artem ShaposhnykoviD· 1 shared Benjamin SchattlingiD· 1 shared Celina Schwencke-Westphal· 1 shared Friederike Reinsberg· 1 shared Imke LieboldiD· 1 shared Jack van HorsseniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Manuel Alexander FrieseORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

HIV-1 promotes cell-to-cell interactions enabling spread from CD4+ T cells to microglia

Friederike Reinsberg, Katharina Schiering, Malte G Lingstaedt, Leonore Mensching, Maisha Adiba, Tom V Kraus, Jan Broder Engler, Imke Liebold, Lidia Bosurgi, Sebastian Schloer, Marcus A. Altfeld, Manuel Alexander Friese, Susanne Krasemann, Ulrike C. Lange, Wilfredo F. García-Beltrán, Angelique Hölzemer

This study shows HIV-1 enhances cell-to-cell transmission from infected CD4+ T cells to microglia by altering surface signals and increasing phagocytosis.

bioRxiv · May 11, 2026 · PreprintImmunology

Tidyplots empowers life scientists with easy code-based data visualization

Jan Broder Engler

Tidyplots provides a user-friendly code-based interface for data visualization, reducing programming barriers for life scientists.

iMeta · Mar 19, 2025Peer-reviewedBioinformatics

Enhancing mitochondrial activity in neurons protects against neurodegeneration in CNS inflammation

Sina Cathérine Rosenkranz, Artem Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E. Witte, Vanessa Roth, Vanessa Vieira, Nanne J. Paauw, Simone Bauer, Celina Schwencke-Westphal, Lukas Can Bal, Benjamin Schattling, Ole Pleß, Jack van Horssen, Marc Freichel, Manuel Alexander Friese

This study shows that enhancing mitochondrial activity in neurons reduces neurodegeneration during CNS inflammation by improving mitochondrial function and calcium buffering.

bioRxiv · Jun 19, 2020 · PreprintNeuroscience