Combined inhibition of S100A4 and TIGIT suppresses late-stage breast cancer metastasis to the lung by activating T and NK cells
Jia-Shiun Leu, Hui Deng, Han Nhat Tran, Wei Xiong, Nourhan Abdelfattah, Thomas K. S. Wong, Reece Kang, Chihiro Hashiomoto, Fransisca Leonard, Sinem Gunalp, José M. Benítez Salazar, José Maldonado, Carlo D. Cristobal, Hyun Kyoung Lee, Zhiqiang An, , Kyuson Yun
This study shows that combining S100A4 and TIGIT inhibition suppresses breast cancer lung metastasis by enhancing T and NK cell activity in late-stage disease.
Cancer Letters · Apr 8, 2026Peer-reviewedCancer Biology