MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
Fereshteh Dorazehi, Caterina Francesconi, Ninoslav Pandiloski, Laura Castilla‐Vallmanya, Anna Albecka, Symela Koutounidou, Sivani Bala Mohan, Anita Adami, Angelos Katsikas, Jana Matijević, Ofelia Karlsson, Carrie Davis-Hansson, Jonas Johansson, Yorgo Modis, Johan Jakobsson, Christopher H. Douse
This study shows MORC2 regulates CpG methylation of active LINE-1 retrotransposons during human neurodevelopment, similar to the piRNA pathway in the germline.
bioRxiv · Jun 11, 2025 · PreprintMolecular Biology