Anna Albecka

The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid

This study shows that the central pore of HIV-1 capsomers, mediated by R18 and K25 rings, is critical for capsid stability and post-entry events, with the N21K mutation compensating for R18 loss.

MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment

This study shows MORC2 regulates CpG methylation of active LINE-1 retrotransposons during human neurodevelopment, similar to the piRNA pathway in the germline.

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

The paper identifies TASOR as a pseudo-PARP essential for HUSH complex assembly and epigenetic repression of transposons.

SARS-CoV-2 infects brain choroid plexus and disrupts the blood-CSF-barrier

This study shows SARS-CoV-2 infects choroid plexus epithelial cells in brain organoids, disrupts the blood-CSF barrier, and may contribute to neurological complications.

MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling

The paper shows MAVS polymers induced by dsRNA are smaller than 80 nm and require the transmembrane domain for mitochondrial remodeling and interferon signaling.