Yorgo Modis

ZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers

This study identifies ZNFX1 as a multifunctional enzyme in innate immunity that couples RNA sensing to ubiquitin signaling and assembles into higher-order structures for signal amplification.

Capsid structures of Atlas viruses reveal an engineerable nanoparticle scaffold

The paper characterizes Atlas virus capsid structures and demonstrates their potential as engineerable nanoparticle scaffolds for targeted nucleic acid delivery.

Crystal structure of HERV-K envelope glycoprotein surface subunit

This paper reports the crystal structure of the HERV-K HML-2 envelope glycoprotein surface subunit, revealing structural features relevant to autoimmunity and drug targeting.

MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment

This study shows MORC2 regulates CpG methylation of active LINE-1 retrotransposons during human neurodevelopment, similar to the piRNA pathway in the germline.

MDA5 variants trade antiviral activity for protection from autoimmune disease

The paper identifies MDA5 variants that protect against autoimmune diseases but increase IBD risk, showing a trade-off between antiviral activity and autoimmunity.

Molecular basis of autoimmune disease protection by MDA5 variants

This study investigates how autoimmune-protective MDA5 variants affect RNA sensing and signaling, finding they reduce interferon response and alter filament formation and ATP hydrolysis.

MDA5 generates compact ribonucleoprotein complexes via ATP-dependent single-stranded RNA loop extrusion

This study shows MDA5 compacts dsRNA via ATP-dependent loop extrusion, stabilizing the structure through CARD domain oligomerization.

A bioactive phlebovirus-like envelope protein in a hookworm endogenous retrovirus

The paper identifies a novel endogenous retrovirus in hookworms with an envelope protein structurally similar to phlebovirus glycoproteins and functional fusogenic activity.

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

The paper identifies TASOR as a pseudo-PARP essential for HUSH complex assembly and epigenetic repression of transposons.

MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling

The paper shows MAVS polymers induced by dsRNA are smaller than 80 nm and require the transmembrane domain for mitochondrial remodeling and interferon signaling.