Identification of the bona fide active center of influenza A virus polymerase acidic protein as the antiviral target
Shan Xu, Xiaoyang Wang, Lihong Zhang, Yanli Tu, Yueqi Wu, Siying Du, Wei Wang, Yigang Tong
The paper identifies the C-terminal domain of influenza A virus PA protein as the active center for endonuclease activity and a novel antiviral target, revealing potential drug resistance mutations and new inhibitors.
bioRxiv · Aug 6, 2025 · PreprintMicrobiology