MicrobiologybioRxivPreprint
Identification of the bona fide active center of influenza A virus polymerase acidic protein as the antiviral target
Shan Xu, Xiaoyang Wang, Lihong Zhang…·Yigang Tong
The paper identifies the C-terminal domain of influenza A virus PA protein as the active center for endonuclease activity and a novel antiviral target, revealing potential drug resistance mutations and new inhibitors.
DOI 10.1101/2025.08.06.669014