TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques
Blanca Tardajos Ayllón, Mannekomba R. Diagbouga, Ankita Das, Siyu Tian, Andreas Edsfeldt, Joanna Maria Kalucka, Jovana Serbanovic‐Canic, Emily V. Chambers, Jiangming Sun, Chrysostomi Gialeli, Mark Dunning, Sheila Francis, Xiuying Li, Akiko Mammoto, Michael Simons, , Paul Charles Evans
Endothelial Twist1 drives partial and advanced endothelial-to-mesenchymal transition via PELP1 and AEBP1-COL4A1 signaling, increasing collagen and ACTA2+ cells to stabilize atherosclerotic plaques in male mice and human carotid arteries.
Nature Communications · Feb 18, 2026Peer-reviewedPathology✦ In-depth digest