Author
University of SheffieldORCID 0000-0001-6552-0339Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Joshua V. Kimble, Charlotte E. Moss, Lilia S Hodge, Martha Clements, Alexandra Rayson, Kellie S Roberts, Ryan J. H. West, Iwan Robert Evans, Sheila Francis, Ilaria Bellantuono, Endre Kiss‐Toth, Heather L. Wilson
This study shows fisetin restores MYC expression in aged macrophages, improving their function and physical performance in older organisms.
bioRxiv · Jun 10, 2026 · PreprintImmunology
Blanca Tardajos Ayllón, Mannekomba R. Diagbouga, Ankita Das, Siyu Tian, Andreas Edsfeldt, Joanna Maria Kalucka, Jovana Serbanovic‐Canic, Emily V. Chambers, Jiangming Sun, Chrysostomi Gialeli, Mark Dunning, Sheila Francis, Xiuying Li, Akiko Mammoto, Michael Simons, , Paul Charles Evans
Endothelial Twist1 drives partial and advanced endothelial-to-mesenchymal transition via PELP1 and AEBP1-COL4A1 signaling, increasing collagen and ACTA2+ cells to stabilize atherosclerotic plaques in male mice and human carotid arteries.
Nature Communications · Feb 18, 2026Peer-reviewedPathology✦ In-depth digest
Beth Eyre, Kira Shaw, Dave Drew, Alexandra Rayson, Osman Shabir, Llywelyn Lee, Sheila Francis, Jason Berwick, Clare Howarth
This study examines vascular function and cognitive performance in mouse models of Alzheimer's disease, atherosclerosis, and their combination, finding hemodynamic deficits in atherosclerosis mice and no differences in amyloid or plaque burden in mixed disease models.
Neurophotonics · May 21, 2025Peer-reviewedNeuroscience
Klaudia Kocsy, Sumeet Deshmukh, Shah Nawaz, A. N. Ali, Sheharyar Sajjad Baig, Joyce Saleh Balami, Arshad Majid, Endre Kiss‐Toth, Sheila Francis, Jessica N.E. Redgrave
This study examines macrophage phenotypes in carotid plaques and shows glucocorticoids can reprogram macrophages to reduce inflammation and lipid uptake, potentially stabilizing atherosclerotic plaques.
Atherosclerosis · Apr 6, 2025Peer-reviewedCell Biology
Beth Eyre, Kira Shaw, Sheila Francis, Clare Howarth, Jason Berwick
The paper examines locomotion-induced hemodynamic responses in different vascular compartments of the whisker barrel cortex in mice, finding an early HbT decrease in draining and meningeal veins.
Neurophotonics · Mar 24, 2025Peer-reviewedNeuroscience
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S. Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul Roy Heath, Stephen B. Wharton, Sheila Francis, Jason Berwick
This study assesses neurovascular coupling and cortical spreading depression in models of atherosclerosis and Alzheimer's disease, finding exacerbated neurovascular decline and increased amyloid-beta plaques in comorbid conditions.
eLife · Dec 20, 2021Peer-reviewedNeuroscience
Osman Shabir, Paul S. Sharp, Monica A Rebollar, Luke W. Boorman, Clare Howarth, Stephen B. Wharton, Sheila Francis, Jason Berwick
The paper investigates neurovascular coupling in J20-hAPP mice under normobaric hyperoxia, finding enhanced cerebral blood volume and potential therapeutic implications for Alzheimer's disease.
Scientific Reports · May 5, 2020Peer-reviewedNeuroscience
Osman Shabir, Ben Pendry, Paul Roy Heath, Monica A Rebollar, Clare Howarth, Stephen B. Wharton, Jason Berwick, Sheila Francis
This study shows that experimental atherosclerosis in mice leads to reduced cortical hemodynamics and neural activity, associated with neuroinflammation and neuronal loss.
bioRxiv · Jan 29, 2020 · PreprintNeuroscience