Joanna Maria Kalucka

The paper creates a single-cell transcriptome atlas of human subcutaneous adipose tissue vascular cells, identifies sub-AdECs, and links their properties to metabolic disease.

This study identifies sex-specific changes in the vascular niche of human adipose tissue in obesity, showing distinct structural and transcriptional differences between males and females.

Endothelial Twist1 drives partial and advanced endothelial-to-mesenchymal transition via PELP1 and AEBP1-COL4A1 signaling, increasing collagen and ACTA2+ cells to stabilize atherosclerotic plaques in male mice and human carotid arteries.

This study examines transcriptional changes in human adipose tissue during weight loss from lifestyle and bariatric surgery, showing significant remodeling and reduced inflammation.

This study creates a comprehensive single-cell transcriptomic atlas of human endothelial cells across adult life, identifying age-related transcriptional changes and a p21-linked senescence program.

This study identifies PDE2A as a regulator of lymphatic endothelial development through cGMP-mediated control of Notch signaling, showing its role in junction maturation and cell cycle arrest.