Helle Færk Jørgensen

Multimodal Hypersampling of the adult human heart resolves tissue-specific cell states and disease-associated variants

This paper creates a detailed heart atlas using multimodal data to identify cell states and disease-associated genetic variants in specific heart regions.

TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques

Endothelial Twist1 drives partial and advanced endothelial-to-mesenchymal transition via PELP1 and AEBP1-COL4A1 signaling, increasing collagen and ACTA2+ cells to stabilize atherosclerotic plaques in male mice and human carotid arteries.

Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilising fibrous cap

The paper identifies a VSMC transition linked to fibrous cap formation in atherosclerosis and shows PAR1 as a potential therapeutic target.

Network-based prioritisation and validation of novel regulators of vascular smooth muscle cell proliferation in disease

The paper identifies and validates novel regulators of vascular smooth muscle cell proliferation using network analysis and experimental validation, highlighting RUNX1 and the TIMP1-CD74 axis as potential therapeutic targets.