A Cationic Amphiphilic Drug (CAD) Defense System in the Nematode Caenorhabditis elegans
Levon Tokmakjian, Duhyun Han, Kateryna Sihuta, Aanchal Aggarwal, Somayeh Pirhadi, Yao Wang, Andrew R. Burns, Brittany Cooke, Siyue Ren, Carolyn L. Cummins, Justin Rea Nodwell, David Ryan Koes, Peter John Roy
This study identifies a CAD defense system in C. elegans involving CYP-35B and PGP-13, showing their roles in CAD metabolism and efflux, and links bacteria to CAD defense activation.
bioRxiv · Jan 3, 2026 · PreprintPharmacology & Toxicology