Peter John Roy

This study shows tioxazafen is bioactivated by cytochrome P450s into a proteasome disruptor, leading to toxicity in nematodes and potential human skin reactions.

This study identifies a CAD defense system in C. elegans involving CYP-35B and PGP-13, showing their roles in CAD metabolism and efflux, and links bacteria to CAD defense activation.

This paper identifies a cytochrome P450 gene variant that contributes to benzimidazole resistance in nematodes, independent of beta-tubulin mutations.

The paper discovers a pro-nematicide scaffold, Cyprocide, that selectively kills diverse plant-parasitic nematodes through P450 enzyme activation, offering a potential solution for sustainable nematode management.

This study develops a yeast whole-cell biocatalyst expressing MHETase for PET degradation, showing comparable activity to purified enzyme and stability under various conditions.

The paper reconstructs the spatiotemporal gene expression blueprint for C. elegans pharyngeal cuticle construction and identifies phase-separating proteins involved in cuticle remodeling.

This study identifies drug modifiers for RYR1-related myopathy using a multi-species pipeline, finding p38 inhibition as a potential therapeutic strategy.

The paper identifies marginal cells in C. elegans pharynx as a sink for hydrophobic small molecules through sphingomyelin synthesis and cholesterol absorption.