Author

Kateryna Sihuta

University of TorontoORCID 0009-0002-9150-6746Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Brittany CookeiD· 3 shared Peter John RoyiD· 3 shared Andrew R. BurnsiD· 2 shared Aanchal AggarwaliD· 1 shared Arthur FlagetiD· 1 shared Bennett William FoxiD· 1 shared Brenda AndrewsiD· 1 shared Briana C. RodrigueziD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersPharmacology & Toxicology

Brittany CookeORCID

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3 papers

Recent·Most cited

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation

L CHEN, Kaiden Thompson, Muntasir Kamal, Kateryna Sihuta, Irini Topalidou, Andrew R. Burns, Nazli H. Farshour, Brittany Cooke, Jessica J. Knox, Yanqing Jiang, Modhar Al Qasser, Ermira Shuteriqi, Matej Ušaj, Justin Ching, Arthur Flaget, , Peter John Roy

This study shows tioxazafen is bioactivated by cytochrome P450s into a proteasome disruptor, leading to toxicity in nematodes and potential human skin reactions.

bioRxiv · Jul 16, 2026 · PreprintPharmacology & Toxicology

A Cationic Amphiphilic Drug (CAD) Defense System in the Nematode Caenorhabditis elegans

Levon Tokmakjian, Duhyun Han, Kateryna Sihuta, Aanchal Aggarwal, Somayeh Pirhadi, Yao Wang, Andrew R. Burns, Brittany Cooke, Siyue Ren, Carolyn L. Cummins, Justin Rea Nodwell, David Ryan Koes, Peter John Roy

This study identifies a CAD defense system in C. elegans involving CYP-35B and PGP-13, showing their roles in CAD metabolism and efflux, and links bacteria to CAD defense activation.

bioRxiv · Jan 3, 2026 · PreprintPharmacology & Toxicology

Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independent of beta-tubulin

J.B. Collins, Clayton M. Dilks, Steffen R. Hahnel, Briana C. Rodriguez, Bennett William Fox, Elizabeth Redman, Jingfang Yu, Brittany Cooke, Kateryna Sihuta, Mostafa Zamanian, Peter John Roy, Frank C. Schroeder, John S. Gilleard, Erik C. Andersen

This paper identifies a cytochrome P450 gene variant that contributes to benzimidazole resistance in nematodes, independent of beta-tubulin mutations.

bioRxiv · Sep 23, 2024 · PreprintGenetics