Divergent roles of DNA methylation, TRIM28, and p53 surveillance in human embryonic and trophoblast stem cells
Deepak Saini, Megan S. Katz, Skye Beck, Taylor E. Ireland, Soma S. Ray, Asef Jawad Niloy, Radman Mazloomnejad, Anna F. Fleming, Sophia C. Vetrici, Jessica K. Cinkornpumin, Tanja Sack, Stéphanie Duhamel, Rima Slim, Morag Park, Jennifer M. Frost, , William A. Pastor
The paper investigates the roles of TRIM28, DNA methylation, and p53 in regulating gene and transposon expression in human embryonic and trophoblast stem cells, revealing divergent responses to genomic instability.
bioRxiv · Oct 19, 2025 · PreprintMolecular Biology