Deepak Saini

The paper investigates the roles of TRIM28, DNA methylation, and p53 in regulating gene and transposon expression in human embryonic and trophoblast stem cells, revealing divergent responses to genomic instability.

The paper shows that efferocytosis by epithelial cells during hormone deprivation in prostate cancer triggers metabolic and gene expression changes that reprogram cells for regeneration.

This study identifies ZMYM2 as essential for DNA methylation and silencing of germline genes and active transposons in embryonic development, revealing its role in maintaining genomic stability.

This study compares the demethylation efficacy and toxicity of GSK-3484862 and 5-azanucleosides in murine embryonic stem cells, finding GSK-3484862 induces more effective demethylation with less toxicity.