Jennifer M. Frost

The paper investigates the roles of TRIM28, DNA methylation, and p53 in regulating gene and transposon expression in human embryonic and trophoblast stem cells, revealing divergent responses to genomic instability.

This study shows that vitamin C increases young LINE-1 element expression in mouse ESCs through H3K9me3 demethylation by KDM4A/C, without increasing somatic insertion rates.

This study identifies endogenous retroviruses that regulate trophoblast gene expression in humans, with implications for pregnancy outcomes.