Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) features CTE-like tau seeds in brain and spinal cord
Nil Saez-Calveras, Bert M. Verheijen, Nabil Morgan, Elizabeth Hill, Prarthna Chabria, Skyler P. Taylor, Kiyomitsu Oyanagi, Akiyoshi Kakita, Yuyu Song, Łukasz A. Joachimiak, Jaime Vaquer‐Alicea, Marc I. Diamond, Ying Lu
This study identifies CTE-like tau seeds in ALS/PDC brain and spinal cord using alanine mutational scanning, suggesting ALS/PDC is a CTE-like tauopathy.
bioRxiv · Jun 26, 2026 · PreprintNeuroscience