Author

Nil Saez-Calveras

The University of Texas Southwestern Medical CenterORCID 0000-0002-9153-9700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:protein structure prediction· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Jaime Vaquer‐AliceaiD· 3 shared Marc I. DiamondiD· 3 shared Charles L. WhiteiD· 2 shared Łukasz A. JoachimiakiD· 2 shared Akiyoshi KakitaiD· 1 shared Ankit GuptaiD· 1 shared Bert M. VerheijeniD· 1 shared Daniel StoddardiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Jaime Vaquer‐AliceaORCID

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3 papers

Recent·Most cited

Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) features CTE-like tau seeds in brain and spinal cord

Nil Saez-Calveras, Bert M. Verheijen, Nabil Morgan, Elizabeth Hill, Prarthna Chabria, Skyler P. Taylor, Kiyomitsu Oyanagi, Akiyoshi Kakita, Yuyu Song, Łukasz A. Joachimiak, Jaime Vaquer‐Alicea, Marc I. Diamond, Ying Lu

This study identifies CTE-like tau seeds in ALS/PDC brain and spinal cord using alanine mutational scanning, suggesting ALS/PDC is a CTE-like tauopathy.

bioRxiv · Jun 26, 2026 · PreprintNeuroscience

Functional classification of tauopathy strains reveals the role of protofilament core residues.

Jaime Vaquer‐Alicea, Victor A. Manon, Vaibhav Bommareddy, Peter Kunach, Ankit Gupta, Jim Monistrol, Valerie A. Perez, Hung Tri Tran, Nil Saez-Calveras, Siling Du, Sushobhna Batra, Daniel Stoddard, Charles L. White, Łukasz A. Joachimiak, Sarah H. Shahmoradian, Marc I. Diamond

The paper identifies amino acids critical for tau strain propagation by analyzing their role in amyloid templating across different tauopathies.

Science Advances · Jan 22, 2025Peer-reviewedNeuroscience

Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy

Nil Saez-Calveras, Jaime Vaquer‐Alicea, Charles L. White, Yogesh Tak, Stephanie Cosentino, Phyllis L. Faust, Elan D. Louis, Marc I. Diamond

This study identifies that tau assemblies in a subset of essential tremor cases with tau pathology are conformationally similar to Alzheimer's disease and primary age-related tauopathy.

Acta Neuropathologica · Jan 8, 2025Peer-reviewedPathology