Bert M. Verheijen

This study shows that mtDNA mutations arising early in life drive age-related pathologies and that mitochondrial fusion modulates their selection, suggesting interventions targeting fusion could slow aging.

This study identifies CTE-like tau seeds in ALS/PDC brain and spinal cord using alanine mutational scanning, suggesting ALS/PDC is a CTE-like tauopathy.

This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.

The paper investigates aggresome formation by reconstituting aggregate transport in Xenopus egg extract, finding that episodic dynein-mediated transport enables positive size selectivity.

The paper shows transcript errors generate amyloid and prion-like proteins in human cells, linking DNA damage to aging and disease.

This study uses cryo-EM to show that tau filaments in ALS/PDC share the CTE fold, suggesting environmental causes for the disease.

The paper estimates transcription fidelity in human cells, identifies factors controlling its accuracy, and links transcription errors to Alzheimer's disease progression.