Yuyu Song

Design of readers for pathological PTM proteoforms in Alzheimer's disease

The paper designs and validates protein readers that specifically detect disease-related modifications in Tau and Abeta in Alzheimer's disease models and human samples.

Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) features CTE-like tau seeds in brain and spinal cord

This study identifies CTE-like tau seeds in ALS/PDC brain and spinal cord using alanine mutational scanning, suggesting ALS/PDC is a CTE-like tauopathy.

Dynamic conformational ensembles of soluble Tau encode neuronal toxicity prior to aggregation

This study identifies dynamic conformational states of soluble Tau that precede aggregation and correlate with neuronal toxicity in Alzheimer's disease and related tauopathies.

m6A modification and prion-like domain proteins converge to dysregulate Neuronal RNA Granules in Alzheimer s disease

This study identifies dysregulation of m6A modification and prion-like domain proteins in Neuronal RNA Granules as potential contributors to Alzheimer's disease pathogenesis.

Lightweight open-source fine-tuning of SAM2 enables domain-specific microscopy segmentation

This paper introduces a lightweight, open-source method to fine-tune SAM2 for microscopy segmentation, achieving high accuracy with small datasets and cross-domain generalization.

Episodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation

The paper investigates aggresome formation by reconstituting aggregate transport in Xenopus egg extract, finding that episodic dynein-mediated transport enables positive size selectivity.

Divergent Molecular Pathways for Toxicity of Selected Mutant C9ORF72-derived Dipeptide Repeats

This study identifies compartment-specific toxic effects of C9ORF72-derived dipeptide repeats (DPRs) in neurodegenerative disease models, revealing two distinct pathogenic mechanisms contributing to ALS and FTD.

HUWE1 Amplifies Ubiquitin Modifications to Broadly Stimulate Clearance of Proteins and Aggregates

This paper identifies HUWE1 as a ubiquitin ligase that enhances ubiquitin modifications on proteins and aggregates, promoting their degradation via proteasome and autophagy pathways.