Akiyoshi Kakita

This study identifies CTE-like tau seeds in ALS/PDC brain and spinal cord using alanine mutational scanning, suggesting ALS/PDC is a CTE-like tauopathy.

This study investigates how dysregulated flow responses in endothelial cells contribute to Sturge-Weber syndrome pathogenesis using cellular models and omics analyses.

This study identifies a role for subarachnoid macrophages in amyloid-beta clearance and vascular dysfunction in Alzheimer's disease using mouse models and intravital imaging.

The paper identifies APOE rare missense variants in the Japanese population and finds two variants associated with protective effects against Alzheimer's disease.

This paper shows how Alzheimer's A{beta} spreads through the neurovascular unit, triggering tau pathology via specific signaling pathways in endothelial and pericyte cells.

This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

This study identifies APP's role in extracellular disposal of nuclear waste, showing its impairment in Alzheimer's disease and suggesting it as a therapeutic target.

The paper identifies region-specific gene isoforms in the human brain using long-read transcriptome sequencing and links them to DNA methylation patterns.

This study identifies a new susceptibility locus, PLA2G4C, for Multiple System Atrophy through a genome-wide association study and functional analysis of a risk variant.

This study uses cryo-EM to show that tau filaments in ALS/PDC share the CTE fold, suggesting environmental causes for the disease.

Cryo-EM structures sort four-repeat tauopathies into three-layered (PSP, GGT, LNT) and four-layered (CBD, AGD, ARTAG, MAPT intron 10 mutations) tau folds, grounding a hierarchical structure-based classification.

The paper shows that age-related DNA demethylation in the TARDBP 3'UTR reduces alternative splicing and increases TARDBP mRNA expression in the human motor cortex, linking this to earlier ALS onset.

The paper maps reciprocal connections between the secondary auditory cortical field (A2) and the lateral amygdala (La) in mice, showing dense innervation and retrograde labeling in La after A2 injection, while other auditory fields show minimal connections.

This study investigates betaine's role in schizophrenia using metabolomics and genetic approaches, finding it may alleviate oxidative stress and improve cognitive function in specific cases.