Pol γ possesses separate metal binding sites for polymerase and strand displacement functions
Noe Baruch‐Torres, Joon Park, Josué Daniel Mora-Garduño, Arkanil Roy, Anupam Singh, Gerardo Andrés Cisneros, Luis Gabriel Brieba, Smita S Patel, Yuhui Whitney Yin
This paper identifies separate metal-binding sites in Pol γ that regulate its DNA synthesis and strand displacement activities, revealing structural and biochemical mechanisms for mitochondrial DNA replication.
Nucleic Acids Research · Jul 17, 2026Peer-reviewedBiochemistry