Author

Sofia C. Guimarães

Universidade do PortoPrimary ORCID profile (0000-0002-3541-177X · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Sofia C. GuimarãesiD2 papers · Universidade do Porto

Biology Disciplines

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Bioengineering· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Eva D. CarvalhoiD· 2 shared Georgia Athanasopoulou· 2 shared Miguel R. G. MoraisiD· 2 shared Ana P. Pêgo· 1 shared Ana Paula PêgoiD· 1 shared Beatriz Rocha Custódio· 1 shared Cristina C. Barrias· 1 shared Eduardo MendesiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Eva D. CarvalhoORCID

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2 papers

Recent·Most cited

Matrix stress-relaxation and stiffness modulate oligodendrocyte differentiation

Eva D. Carvalho, Miguel R. G. Morais, Georgia Athanasopoulou, Marco Araújo, Sofia C. Guimarães, Stefano Pluchino, Cristina C. Barrias, Ana P. Pêgo

This study shows that viscoelastic properties of 3D hydrogels impact oligodendrocyte differentiation and function, suggesting mechanotransduction as a target for remyelination therapies.

bioRxiv · Oct 9, 2025 · PreprintNeuroscience

Engineered micropillars to unveil oligodendrocyte responses to physical cues

Eva D. Carvalho, Miguel R. G. Morais, Helena P. Ferreira, Georgia Athanasopoulou, Hendrik Hubbe, Rui Rocha, M. Mattarelli, Beatriz Rocha Custódio, Sofia Assis, Shuyao Daniela Gu, Kashmyr A. Y. P. Dalang, Samuel Levi Rosemore, Wolfgang Losert, María Gómez-Lázaro, Silvia Caponi, , Ana Paula Pêgo

This paper develops a tissue-engineered model to study how physical cues like stiffness and axonal diameter affect oligodendrocyte myelination, finding that softer substrates promote differentiation while rigid ones maintain mature states.

bioRxiv · Mar 16, 2025 · PreprintBioengineering