Stefano Pluchino

The paper surveys awareness of extracellular vesicles' translational potential across academia and industry, highlighting growing interest and spin-out efforts in EV-based products.

This study shows that viscoelastic properties of 3D hydrogels impact oligodendrocyte differentiation and function, suggesting mechanotransduction as a target for remyelination therapies.

This study identifies ceruloplasmin deficiency in mutant astrocytes as a driver of iron toxicity and neurodegeneration in a Parkinson's tri-culture model.

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.

The paper identifies mitochondrial reverse electron transport in myeloid cells as a driver of neuroinflammation and shows that blocking it protects the CNS in disease models.

The paper investigates the neuroprotective effects of small extracellular vesicles from region-specific astrocytes in Parkinson's disease, showing they improve mitochondrial function.

The paper uses single-cell RNA sequencing to characterize human iPSC-derived spinal motor neuron subtypes and identifies their molecular profiles.

This study shows neural stem cells transfer functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells, improving disease outcomes in multiple sclerosis.