Cyanine dye conjugates of a 2'-deoxycytidine-based auto- and mitophagy activator extend Caenorhabditis elegans lifespan
Ekaterina A. Guseva, Polina N. Kamzeeva, Sofya Y. Sokolskaya, Boris P Myasnikov, Julia A. Golubeva, Vera A. Alferova, Rose-Lys Zaranaina, Valeriya B. Vays, Irina M. Vangeli, E. G. Belyaev, Olga A. Potapova, Natalia N. Gotmanova, Anna V. Bacheva, Lora E. Bakeeva, Elena Marusich, , Andrey V. Aralov
The paper identifies a 2'-deoxycytidine-based compound that activates autophagy and mitophagy, extends C. elegans lifespan when conjugated with a mitochondria-targeting dye.
bioRxiv · Jan 25, 2026 · PreprintPharmacology & Toxicology