Somaya A. Abdel‐Rahman

This study identifies small molecule inhibitors of ILT3 using AS-MS, showing they improve cognition and reduce amyloid in Alzheimer's disease models.

This study identifies small molecule modulators of ILT3, a myeloid immune checkpoint, showing anti-tumor efficacy in preclinical models.

ClinOracle uses a hierarchical graph neural network to predict target binding and patient-derived functional activity, improving compound prioritization through a Priority Score combining translational probability and developability.

HTS-Oracle X uses deep learning to identify small molecule binders of immune checkpoint proteins with high enrichment and sub-micromolar affinity.

HTS-Oracle v2 improves hit discovery for immunotherapy targets by selecting fewer compounds for experimental testing while maintaining high validation rates.

This study identifies APX1 as a small molecule that targets LILRB4, modulating microglial immune suppression and improving AD symptoms in a mouse model.

OracleScreen-LILRB4 identifies small molecule binders of LILRB4 using machine learning, achieving high hit rates and validating compounds in patient-derived cells.

This study uses HT-CETSA to identify small molecule modulators of ILT3, showing functional activity in human iPSC-derived microglia for Alzheimer's disease.

This paper identifies small molecule inhibitors of LILRB4 that reduce amyloid pathology and improve cognition in a mouse model of Alzheimer's disease.

The paper develops a TR-FRET assay to identify small molecule inhibitors of the LILRB4-SCG2 immune checkpoint interaction, identifying two compounds with dose-dependent inhibition.

This paper computationally designs and experimentally validates macrocyclic peptides that inhibit SLIT2/ROBO1 interaction, showing promising in vitro properties.

This study designs and validates the first-in-class PROTACs for LAG-3 degradation, showing dose-dependent reduction in LAG-3 protein levels in Raji-LAG3 cells.

This paper identifies and optimizes a potent small molecule LAG-3 inhibitor using DNA-encoded chemical library screening for cancer immunotherapy.

This paper discovers and validates a first-in-class small molecule inhibitor of the SLIT2/ROBO1 interaction using DNA-encoded library screening and demonstrates its functional inhibition and ADME properties.