Nelson García-Vázquez

Discovery and Optimization of Small Molecule Inhibitors of the SLIT2/ROBO1 Protein-Protein Interaction Using DNA-Encoded Libraries

This study discovers and optimizes small molecule inhibitors of the SLIT2/ROBO1 protein-protein interaction using DNA-encoded libraries, achieving improved binding affinity and functional potency.

Ligandability Assessment of the LAG-3 D1 Domain Enables Discovery of a Small-Molecule Inhibitor

The paper assesses the ligandability of the LAG-3 D1 domain using molecular dynamics, virtual screening, and biochemical assays, identifying a small-molecule inhibitor with micromolar affinity.

Virtual Screening-Guided Discovery of Small Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids

This study identifies two small molecule CHI3L1 inhibitors using virtual screening and validates their activity in glioblastoma spheroids.

Design and Validation of the First-in-Class PROTACs for Targeted Degradation of the Immune Checkpoint LAG-3

This study designs and validates the first-in-class PROTACs for LAG-3 degradation, showing dose-dependent reduction in LAG-3 protein levels in Raji-LAG3 cells.

Discovery and Optimization of LAG-3-Targeted Small Molecules via DNA-Encoded Chemical Library (DEL) Screening for Cancer Immunotherapy

This paper identifies and optimizes a potent small molecule LAG-3 inhibitor using DNA-encoded chemical library screening for cancer immunotherapy.

TRIC Coupled with TR-FRET as a High-Throughput Screening Platform for the Discovery of SLIT2 Binders: A Proof-of-Concept Approach

This paper presents a high-throughput screening platform combining TRIC and TR-FRET to identify SLIT2 binders, finding bexarotene as a potent inhibitor with a KD of 2.62 μM.

Discovery of a First-in-Class SLIT2 Binder Disrupting the SLIT2/ROBO1 Axis via DNA-Encoded Library (DEL) Screening

This paper discovers and validates a first-in-class small molecule inhibitor of the SLIT2/ROBO1 interaction using DNA-encoded library screening and demonstrates its functional inhibition and ADME properties.

Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

The paper shows cyclin D1-CDK4/6 stabilizes GTSE1, promoting cell proliferation and poor cancer prognosis.