Single-Cell and Spatial Methods for Multimodal Functional Glycan Profiling in Tissues
A.K. Basak, Carolina Ortiz‐Cordero, Stephanie Pei Tung Yiu, Sidney Allison, Sarah Sweeting, Feng Shan, Yuzhou Evelyn Tong, Rajeev S. Chorghade, Alexxandra Sosa-Guir, Somkene D. Alakwe, Constantine N. Tzouanas, Bokai Zhu, Adele Gabba, Yao Yu Yeo, Wenrui Wui, , Laura L. Kiessling
The paper introduces two methods to profile functional glycan-lectin interactions in tissues using single-cell and spatial multiomic approaches, revealing stimulus-specific glycan remodeling and spatial glycan programs in immune cells and follicular lymphoma.
bioRxiv · Feb 24, 2026 · PreprintMolecular Biology