Constantine N. Tzouanas

The paper develops scalable cell-free protein synthesis platforms to generate single-cell RNA-sequencing data on immune cell responses to cytokines and other signals, enabling functional discovery and drug target prioritization.

This paper develops a method to grow engineered liver tissue in vivo by using synthetic biology to trigger on-demand expansion after implantation.

The paper introduces two methods to profile functional glycan-lectin interactions in tissues using single-cell and spatial multiomic approaches, revealing stimulus-specific glycan remodeling and spatial glycan programs in immune cells and follicular lymphoma.

The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.

This study shows that dietary lipids, not ketone body metabolites, drive intestinal tumorigenesis in ketogenic diets, highlighting the role of fatty acid oxidation.

This study shows Hydra vulgaris maintains stable thermal responses despite losing half its neurons through caloric restriction or surgery.

The paper introduces a method to spatially label and isolate cells using photoactivatable dyes, demonstrating its application in organoids and tissue sections to study spatial gene expression and cell behavior.

The paper proposes that magnetic fields can alter the magnetic entropy of biogenic nanoparticles, potentially triggering temperature-sensitive ion channels to create magnetogenetic effects.

The paper develops a two-state photoconversion model to predict and program gene expression dynamics in optogenetic systems with high accuracy.