Author

Alexxandra Sosa-Guir

Massachusetts Institute of TechnologyORCID 0000-0002-3891-6896Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:multiome· 1 Assay:proteomics· 1

Frequent Co-Authors

Carolina Ortiz‐CorderoiD· 2 shared Eric J CarpenteriD· 2 shared Laura L. KiesslingiD· 2 shared Ratmir DerdaiD· 2 shared Shreyas GuptaiD· 2 shared A.K. BasakiD· 1 shared Adele GabbaiD· 1 shared Alex K. ShalekiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Carolina Ortiz‐CorderoORCID

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2 papers

Recent·Most cited

Biological recognition of mirror-image glycans

Chuanhao Peng, Simatsidk Haregu, Claire Yi-Ling Yang, Shreyas Gupta, Michael Evjen, Hani Choksi, Vanessa Affe, Eric J Carpenter, Nicholas M. Twells, Mei-Ting Lin, Ayodeji Kulepa, Carolina Ortiz‐Cordero, Alexxandra Sosa-Guir, Jonathan Lefèbre, Szu Yun Wang, , Ratmir Derda

The paper evaluates how glycan-binding proteins and immune cells recognize mirror-image glycans, finding widespread binding and donor-specific recognition of L-glycans.

bioRxiv · Jul 20, 2026 · PreprintBiochemistry

Single-Cell and Spatial Methods for Multimodal Functional Glycan Profiling in Tissues

A.K. Basak, Carolina Ortiz‐Cordero, Stephanie Pei Tung Yiu, Sidney Allison, Sarah Sweeting, Feng Shan, Yuzhou Evelyn Tong, Rajeev S. Chorghade, Alexxandra Sosa-Guir, Somkene D. Alakwe, Constantine N. Tzouanas, Bokai Zhu, Adele Gabba, Yao Yu Yeo, Wenrui Wui, , Laura L. Kiessling

The paper introduces two methods to profile functional glycan-lectin interactions in tissues using single-cell and spatial multiomic approaches, revealing stimulus-specific glycan remodeling and spatial glycan programs in immune cells and follicular lymphoma.

bioRxiv · Feb 24, 2026 · PreprintMolecular Biology