Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease
Jessica Lisa Villalba-Moreno, Yassir El‐Amri, K I Kim, Nelson David Villalba‐Moreno, Mohsin Shafiq, Carolina Ortiz‐Cordero, Shiwei Wang, Jose Alejandro Ossa, Isaura Suárez-Uribe, Duvan Cardona‐Madrigal, Andrés Villegas, Markus Glatzel, Susanne Krasemann, Rafael Posada‐Duque, Laura L. Kiessling, , Diego Sepúlveda Falla
The paper identifies astrocyte-driven small vessel disease as an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease through proteomic and transcriptomic analyses.
bioRxiv · Jul 22, 2026 · PreprintNeuroscience